{"id":18567,"date":"2024-04-02T07:49:51","date_gmt":"2024-04-02T07:49:51","guid":{"rendered":"https:\/\/2023.re-check.ch\/?page_id=18567"},"modified":"2026-01-23T08:24:50","modified_gmt":"2026-01-23T08:24:50","slug":"hpv-vaccination-2","status":"publish","type":"page","link":"https:\/\/www.re-check.ch\/en\/projects\/hpv-vaccination-2\/","title":{"rendered":"HPV Vaccination"},"content":{"rendered":"\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/www.re-check.ch\/wp-content\/uploads\/2024\/02\/HPV-vaccination_big.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"450\" src=\"https:\/\/www.re-check.ch\/wp-content\/uploads\/2024\/02\/HPV-vaccination_big.jpg\" alt=\"\" class=\"wp-image-18480\" srcset=\"https:\/\/www.re-check.ch\/wp-content\/uploads\/2024\/02\/HPV-vaccination_big.jpg 650w, https:\/\/www.re-check.ch\/wp-content\/uploads\/2024\/02\/HPV-vaccination_big-300x208.jpg 300w\" sizes=\"(max-width: 650px) 100vw, 650px\" \/><\/a><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Since 2008 Catherine Riva and Serena Tinari are investigating the case of HPV vaccination. It\u2019s an issue of public interest, as these vaccines are recommended to millions of healthy individuals.<\/p>\n\n\n\n<p>You\u2019ll find below all our publications, open letters, posters, and the regulatory documents we have obtained from the US Food and Drug Administration (FDA) through a Freedom of Information Act (FOIA) request.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:31px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Recent publications<\/h2>\n\n\n\n<div class=\"block-accordeon\">\n      <ul class=\"accordion\" data-accordion data-multi-expand=\"true\" data-allow-all-closed=\"true\">\n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">In December 2020, Catherine Riva and MD Jean-Pierre Spinosa published on the Journal of Scientific Practice and Integrity the article \u201cHas the HPV vaccine approval ushered in an era of over-prevention?\u201d.<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p>The article analyzes unpublished documents from the US Food and Drug Administration (FDA). This original research, published on December 2, 2020 in the open access Journal of Scientific Practice and Integrity, highlights the cascade of problematic decisions that led to the approval of Gardasil\u00ae, Merck\u2019s quadrivalent HPV vaccine. The article is part of a long-term investigative effort that began in 2008 and shows that under the pressure of an unjustified fast-track procedure, US regulatory authorities failed to comply with the methodological guidelines that are supposed to be applied in drugs and vaccines approval (ICH guidelines). As a result, almost 15 years after its approval it is impossible to know what the true benefit-risk ratio of HPV vaccination is. Furthermore, in industrialized countries Gardasil\u00ae approval has generated a constellation of \u201cover-prevention\u201d that allows Merck to be freed from the burden of proof, while generating huge profits. Meanwhile, health authorities promote these products, and the society bears the costs of both the vaccination campaigns and the vaccine&#8217;s potential health risks.<\/p>\n<p>Article for lay person available <a href=\"\/en\/gardasil-approval-over-prevention\/\" target=\"_blank\" rel=\"noopener\">here<\/a> | Publication available <a href=\"https:\/\/www.re-check.ch\/wp-content\/uploads\/2026\/01\/18180-has-the-hpv-vaccine-approval-ushered-in-an-era-of-over-prevention-4.pdf\" target=\"_blank\" rel=\"noopener\">here<\/a><\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">In December 2018, Catherine Riva, Serena Tinari and MD Jean-Pierre Spinosa published an analysis of the Cochrane HPV vaccines review on the British Medical Journal&#8217;s BMJ-Evidence-Based Medicine: \u201cLessons learnt on transparency, scientific process and publication ethics. The short story of a long journey to get into the public domain unpublished data, methodological flaws and bias of the Cochrane HPV vaccines review\u201d.<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p>The news in 2012 that Cochrane was going to review the evidence on HPV vaccines made us hopeful \u2013 finally, we thought, someone will set the records straight about the flawed science behind the claim that this vaccine is appropriate, safe and effective. Cochrane meta-analyses are indeed considered the gold standard to assess public health interventions\u2019 benefits and risks. Its reviews are supposed to apply evidence-based medicine methods on the best\u00a0available evidence, and adhere to strict ethical guidelines. So yes, we were really glad Cochrane was working on this review.<\/p>\n<p>However, the first review protocol in 2014 was riddled with methodological flaws and the authors\u2019 panel had many conflicts of interest. You can read in our Chronology the details of how many times we took contact with Cochrane, through the established platforms, to share our concerns about these shortcomings. Our communications were co-signed by several Canadian public health researchers. Our efforts didn\u2019t bring a result though.<\/p>\n<p>The Cochrane review was finally published six years later, and it comes with many methodological and ethical flaws. According to evidence-based medicine, such issues void Cochrane review\u2019s positive conclusions on the efficacy of HPV vaccines. The conflicts of interest in the authors&#8217; panel weren&#8217;t addressed, nor resolved.<\/p>\n<p>Our experience shows that on HPV vaccines Cochrane has failed to respect its basic principles. We ultimately decided to publish on the open-source platform Zenodo.org our correspondence with Cochrane, as the collection provides the evidence that the organization had many opportunities to make use of our findings. In our BMJ-Evidence-Based Medicine paper and on Zenodo.org all data and tables to support our conclusions are available. At least they are in the public domain, for the scientific and medical community and for the public to read.<\/p>\n<p>Press release available <a href=\"https:\/\/www.re-check.ch\/en\/cochranes-hpv-vaccines-review\/\" target=\"_blank\" rel=\"noopener\">here<\/a> | Publication available <a href=\"https:\/\/www.re-check.ch\/wp-content\/uploads\/2026\/01\/2018-12-06_BMJEBM_RivaC-TinariS-SpinosaJP_Letter-Cochrane-HPV-vaccines-review.pdf\" target=\"_blank\" rel=\"noopener\">here<\/a><\/p>\n          <\/div>\n        <\/li>\n        \n          <\/ul>\n  <\/div>\n\n\n\n\n<h2 class=\"wp-block-heading\">Chronology of the work we have done<\/h2>\n\n\n\n<div class=\"block-accordeon\">\n      <ul class=\"accordion\" data-accordion data-multi-expand=\"true\" data-allow-all-closed=\"true\">\n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2008<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>March 2008:<\/strong> Catherine Riva published an investigation in the Swiss newspaper Le Matin dimanche (<a href=\"https:\/\/www.amge.ch\/2008\/03\/31\/vaccin-contre-le-cancer-du-col-de-l%E2%80%99uterus-nous-a-t-on-tout-dit\/\" target=\"_blank\" rel=\"noopener\">\u201cVaccin contre le cancer du col de l\u2019ut\u00e9rus: nous a-t-on tout dit?\u201d<\/a>, in French. Cervical cancer vaccine: have we got all the available information?) on the launch of Gardasil\u00ae, revealing the existence of an innovative marketing apparatus, selective reporting of the RCTs results, and conflicts of interest within the Swiss Federal Vaccines Commission (EKIF\/CFV).<\/p>\n<p><strong>August 2008:<\/strong> Serena Tinari documentary on HPV vaccines was broadcasted by Swiss public TV program Fal\u00f2 RSI (<a href=\"http:\/\/www.serenatinari.com\/hpv-vaccine\/\" target=\"_blank\" rel=\"noopener\">\u201cUna speranza e qualche dubbio\u201d<\/a>, in Italian. A shred of hope, and some doubts).<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2010<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>March 2010:<\/strong> Catherine Riva and MD Jean-Pierre Spinosa published the investigative <a href=\"https:\/\/editions-xenia.com\/livres\/hpv\/\" target=\"_blank\" rel=\"noopener\">book<\/a> on HPV vaccines \u201cLa piq\u00fbre de trop?\u201d (in French, Xenia 2010. One Injection Too Many?).<\/p>\n<p><strong>October 2010:<\/strong>\u00a0Serena Tinari documentary on HPV vaccines was broadcasted by the Swiss public TV shows Fal\u00f2 RSI (in Italian: <a href=\"http:\/\/www.serenatinari.com\/hpv-vaccine\/\" target=\"_blank\" rel=\"noopener\">\u201cDalla parte delle bambine\u201d<\/a>. On the girls&#8217; side) and by Rundschau SRF (in German: <a href=\"https:\/\/www.srf.ch\/play\/tv\/rundschau\/video\/umstrittene-impfung?urn=urn:srf:video:db70e93b-588f-4324-8909-e98872cc885d&amp;station=69e8ac16-4327-4af4-b873-fd5cd6e895a7\" target=\"_blank\" rel=\"noopener\">\u201cUmstrittene Impfung\u201d<\/a>. A controversial vaccine).<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2011<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>May 2011:<\/strong> Jean-Pierre Spinosa and Catherine Riva published with Clinical pharmacology Professor Emeritus J\u00e9r\u00f4me Biollaz a letter to the editor of Cancer Letters, responding to the article of Luisa Lina Villa \u201cHPV prophylactic vaccination: The first years and what to expect from now\u201d. They signaled the results listed in an unpublished VRBPAC background document, showing that Gardasil\u00ae failed to demonstrate the expected efficacy in preventing CIN\u00a02+ irrespective of HPV type. doi: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0304383511000504?via%3Dihub\">10.1016\/j.canlet.2011.01.024<\/a><a href=\"https:\/\/api.istex.fr\/ark:\/67375\/6H6-T5QTJB70-C\/fulltext.pdf?sid=istex-browser-addon\" target=\"_blank\" rel=\"noopener\">ISTEX<\/a><\/p>\n<p><strong>June 2011:<\/strong> After a three-year procedure, the Swiss Federal Administrative Court <a href=\"https:\/\/www.fr.ch\/sites\/default\/files\/contens\/atprd\/_www\/files\/pdf45\/A-3192_20101.pdf\" target=\"_blank\" rel=\"noopener\">ruled <\/a>in favor of Catherine Riva and ordered the Swiss Federal Office of Public Health to grant her access to the conflicts of interest disclosures of the Swiss Federal Commission for Vaccination (FCV) that were kept confidential.<\/p>\n<p><strong>October 2011:<\/strong> Catherine Riva and Jean-Pierre Spinosa were invited by the independent medical association Med\u2019Ocean to a <a href=\"https:\/\/www.medocean.re\/actions\/item\/44-le-gardasil-a-l-assemblee-nationale\" target=\"_blank\" rel=\"noopener\">roundtable<\/a> on HPV vaccination at the Assembl\u00e9e Nationale (french Parliament) in Paris, France. Their presentation focused on efficacy issues in the case of Gardasil\u00ae and on concerns about the way its approval was managed by the US Food and Drug Administration FDA (fast track, outcomes\u2019 choice, selective reporting).<\/p>\n<p><strong>November 2011:<\/strong>\u00a0Catherine Riva published an investigative article in the Swiss magazine Femina (<a href=\"http:\/\/www.femina.ch\/societe\/sante\/jeunes-filles-cobayes-dun-vaccin-preuves\" target=\"_blank\" rel=\"noopener\">\u201cLes jeunes filles cobayes d\u2019un vaccin qui n\u2019a pas fait ses preuves\u201d<\/a>, in French. Girls as Guinea pigs of a vaccine that hasn&#8217;t been yet properly assessed) that included unpublished data she obtained from the FDA through Freedom of Information Act (FOIA) request. The data indicate that &#8220;outcome switching&#8221;, a highly controversial practice as it may impact the study results, affected Gardasil\u00ae Phase III trials. The article also showed that the Swiss Federal Commission for Vaccination (FCV) modified its conflicts of interest disclosure policy, a decision that has ultimately led to less transparency.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2012<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>December 2012:<\/strong> Catherine Riva, Jean-Pierre Spinosa, Abby Lippman, Neil Arya, Pierre Biron, Genevi\u00e8ve Rail, Lyba Spring, Anne Taillefer and Fernand Turcotte signaled in a referenced comment sent to Cochrane their concerns about undisclosed conflicts of interest among the authors of the planned Cochrane HPV vaccines review. Cochrane, contrary to its own policy, didn\u2019t publish the comment on its website.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2013<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>July 2013:<\/strong> The journal Prescrire published a letter Catherine Riva and Jean-Pierre Spinosa had submitted to the journal in March 2012 that addressed, among other issues, Prescrire\u2019s statements in favor of HPV vaccination and the lack of evidence to support them.\u00a0The authors considered the <a href=\"http:\/\/www.prescrire.org\/fr\/3\/31\/49012\/0\/NewsDetails.aspx\" target=\"_blank\" rel=\"noopener\">journal response<\/a> unsatisfactory, and in a further <a href=\"https:\/\/zenodo.org\/record\/2025773\" target=\"_blank\" rel=\"noopener\">reply<\/a> underlined undisclosed conflicts of interest in the Prescrire editorial board.<\/p>\n<p><strong>December 2013:<\/strong> Catherine Riva, Jean-Pierre Spinosa, Abby Lippman, Neil Arya, Pierre Biron, Genevi\u00e8ve Rail, Lyba Spring, Anne Taillefer and Fernand Turcotte sent to Cochrane an email with 3 attachments: a new letter; once more, their December 2012 comment and the analytical listing of the Cochrane review authors&#8217; panel conflicts of interest. Cochrane replied to the group and reassured them, that the review authors\u2019 panel composition had changed.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2014<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>Summer 2014:\u00a0<\/strong>In July 2014 Catherine Riva received from Prof. Ingrid M\u00fchlhauser (Hamburg University) the detailed protocol of the planned Cochrane HPV vaccines review. In August 2014 Catherine Riva, Jean-Pierre Spinosa, Abby Lippman, Neil Arya, Pierre Biron, Genevi\u00e8ve Rail, Lyba Spring, Anne Taillefer and Fernand Turcotte submitted to Cochrane a new comment with suggestions to improve the protocol. In the comment, they made the Cochrane review authors aware about the unpublished data Catherine Riva obtained from the FDA through a FOIA request regarding Gardasil\u00ae efficacy in preventing all CIN 2+ irrespective of HPV type and of the outcome switching in the Gardasil\u00ae Phase III studies.<\/p>\n<p><strong>September 2014: <\/strong>Catherine Riva and Jean-Pierre Spinosa sent a <a href=\"https:\/\/zenodo.org\/record\/2025780\" target=\"_blank\" rel=\"noopener\">rebuttal<\/a> to Mich\u00e8le Rivasi and Prof. Henri Joyeux who were disseminating in social and mainstream media flawed information on HPV vaccines\u2019 efficacy, Pap test, aluminum toxicity and observational studies\u2019 results.<\/p>\n<p><strong>October 2014: <\/strong>Serena Tinari authored for the Swiss public TV show Rundschau SRF a story on HPV vaccines reported adverse events. &#8220;Umstrittene Impfung&#8221; (A controversial vaccine) is available <a href=\"https:\/\/www.srf.ch\/news\/schweiz\/schweiz-verdacht-auf-schwere-nebenwirkung-bei-krebspraevention-fuer-maedchen\" target=\"_blank\" rel=\"noopener\">in German<\/a>. Catherine Riva published on the Swiss magazine Sept.club an extensive <a href=\"https:\/\/sept.club\/vaccination-anti-hpv-tirer-les-enseignements-du-dossier-muhlethaler\/\" target=\"_blank\" rel=\"noopener\">comment<\/a> about the issues featured in the documentary.<\/p>\n<p><strong>December 2014: <\/strong>Catherine Riva published on the Swiss magazine Sept.club a <a href=\"https:\/\/sept.club\/vaccination-anti-hpv-loms-en-flagrant-delit-de-nimporte-quoi\/\" target=\"_blank\" rel=\"noopener\">critical comment<\/a> on WHO\u2019s HPV Handbook methodological flaws and the conflicts of interest among its authors. Meanwhile, four months after submission, the comment on Cochrane HPV vaccines review protocol still hadn\u2019t been published on the Cochrane dedicated website. Catherine Riva, Jean-Pierre Spinosa, Abby Lippman, Neil Arya, Pierre Biron, Genevi\u00e8ve Rail, Lyba Spring, Anne Taillefer and Fernand Turcotte wrote again to Cochrane<strong>.<\/strong><\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2015<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>February 2015: <\/strong>The comment on Cochrane HPV vaccines review protocol submitted in August 2014 was finally published on the Cochrane dedicated website. The comment on the protocol and the review authors\u2019 reply is no more available, since Cochrane erased all comments on the HPV vaccines review protocol after the review was published in May 2018.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2017<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>April 2017: <\/strong>Re-Check published a <a href=\"https:\/\/www.re-check.ch\/fr\/le-big-business-du-typage-de-hpv\/\" target=\"_blank\" rel=\"noopener\">piece<\/a> on the lucrative market of HPV testing, that is being expanded with the new era of the HPV vaccines marketing. This technique comes with a false-positive rate almost five times higher than cytology screening, leading to an increased demand for additional testing, and potentially causing overdiagnosis.<\/p>\n<p><strong>December 2017: <\/strong>Catherine Riva and Jean-Pierre Spinosa published on the Swiss magazine Sept.club an <a href=\"https:\/\/sept.club\/vaccination-anti-hpvle-ver-est-dans-le-fruit-depuis-dix-ans\/\" target=\"_blank\" rel=\"noopener\">open letter<\/a> on HPV vaccination, focusing on methodological shortcomings in the approval process, and conflicts of interest.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2018<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>May 2018:\u00a0<\/strong>Cochrane published its HPV vaccines review &#8220;Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors<em>&#8220;<\/em>. doi: <a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD009069.pub3\/full\" target=\"_blank\" rel=\"noopener\">10.1002\/14651858.CD009069.pub3<\/a>.<\/p>\n<p><strong>June 2018:\u00a0<\/strong>Catherine Riva, Serena Tinari and Jean-Pierre Spinosa submitted to Cochrane a <a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD009069.pub3\/detailed-comment\/en?messageId=154255807\" target=\"_blank\" rel=\"noopener\">critical comment<\/a> on its HPV vaccines review. It highlights methodological flaws in the review: (a) studies quality not properly assessed; (b) post-hoc subgroup analyses presented as RCT results; (c) reporting bias not acknowledged; (d) selective reporting not taken into consideration; (e) biased trial designs; (f) unpublished data not included; (g) conflicts of interest in the authors\u2019 panel; (h) n=7 studies on Gardasil\u00ae included, n=18 for Cervarix\u00ae \u2013 the latter not being marketed in the US anymore. The comment was published over three months after submission and without the tables.<\/p>\n<p><strong>August 2018:<\/strong> Catherine Riva and Serena Tinari presented at the 2018 Preventing Overdiagnosis Conference (PODC) a <a href=\"https:\/\/zenodo.org\/record\/2023152\" target=\"_blank\" rel=\"noopener\">poster<\/a> in conversation on \u201cGhost Management in Medicine and Public Health\u201d that included two maps about the HPV vaccines. The abstract was published in a special edition of BMJ-Evidence-Based Medicine. doi: <a href=\"https:\/\/ebm.bmj.com\/content\/23\/Suppl_2\/A49.3.info\" target=\"_blank\" rel=\"noopener\">10.1136\/bmjebm-2018-111070.105<\/a>. Catherine Riva and Serena Tinari participation to the conference was supported by the Oxford Center for Evidence-Based Medicine (CEBM) and by the Fondation pour l\u2019Encouragement de la Recherche en Pharmacologie Clinique (Lausanne, Switzerland).<\/p>\n<p><strong>December 2018:<\/strong> Catherine Riva, Serena Tinari and Jean-Pierre Spinosa published the complete correspondence with Cochrane, including tables and data, on the open-access platform Zenodo.org. They submitted a Letter to the editor of the BMJ-Evidence-Based Medicine that was published online first on December 6, doi: <a href=\"http:\/\/dx.doi.org\/10.1136\/bmjebm-2018-111119\" target=\"_blank\" rel=\"noopener\">10.1136\/bmjebm-2018-111119<\/a><\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2019<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>January 2019:<\/strong> Catherine Riva was featured in the article <a href=\"https:\/\/www.parismatch.com\/Actu\/Sante\/Rien-ne-justifie-de-recommander-le-vaccin-Gardasil-contre-les-infections-au-papillomavirus-1599033\" target=\"_blank\" rel=\"noopener\">\u201cRien ne justifie de recommander le vaccin Gardasil contre les papillomavirus\u201d<\/a> (In French. Nothing justifies recommending Gardasil vaccine against HPV). Published by Paris-Match.<\/p>\n          <\/div>\n        <\/li>\n        \n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">2020<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p><strong>December 2020:<\/strong> Catherine Riva and Jean-Pierre Spinosa published on the open access Journal of Scientific Practice and Integrity the original research and commentary \u201cHas the HPV vaccine approval ushered in an era of over-prevention?\u201d, doi: <a href=\"http:\/\/dx.doi.org\/10.1136\/bmjebm-2018-111119\" target=\"_blank\" rel=\"noopener\">110.35122\/001c.18180<\/a><\/p>\n          <\/div>\n        <\/li>\n        \n          <\/ul>\n  <\/div>\n\n\n\n\n<h2 class=\"wp-block-heading\">Cochrane HPV vaccines review<\/h2>\n\n\n\n<div class=\"block-accordeon\">\n      <ul class=\"accordion\" data-accordion data-multi-expand=\"true\" data-allow-all-closed=\"true\">\n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">Between December 2012 and September 2018, Catherine Riva, Serena Tinari (since June 2018) and Jean-Pierre Spinosa corresponded with Cochrane (CGNOC) and Cochrane Library on the Cochrane systematic review on HPV vaccines. It entailed:<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <ul>\n<li>Comments (2012-2014 *\/**) addressing undisclosed conflicts of interest among the Cochrane review authors and making suggestions to improve the review protocol (<a href=\"https:\/\/zenodo.org\/record\/1434601\" target=\"_blank\" rel=\"noopener\">here<\/a>)<\/li>\n<li>Email (2015*) about the concerning fact that the lead author of the Cochrane HPV vaccine review had publicly presented intermediate results at a congress (<a href=\"https:\/\/zenodo.org\/record\/1434757\" target=\"_blank\" rel=\"noopener\">here<\/a>)<\/li>\n<li>Expos\u00e9 (2015*) summarizing concerns and correspondence 2012-2015 (<a href=\"https:\/\/zenodo.org\/record\/1434780\">here<\/a>)<\/li>\n<li>Comment (2018) on methodological flaws in the HPV vaccines review and unresolved conflicts of interest in the authors&#8217; panel (<a href=\"https:\/\/zenodo.org\/record\/1434748\" target=\"_blank\" rel=\"noopener\">here<\/a> and <a href=\"https:\/\/zenodo.org\/record\/1434763\" target=\"_blank\" rel=\"noopener\">here<\/a>). Especially, this comment entails:\n<ul>\n<li>tables showing how in the Gardasil\u00ae studies the definition of the subgroup \u201cnegative to 14 HPV types\u201d population (RMITT-2) changed several times between 2006 and 2010 (<a href=\"https:\/\/zenodo.org\/record\/1434229\" target=\"_blank\" rel=\"noopener\">here<\/a> and <a href=\"https:\/\/zenodo.org\/record\/1435032\" target=\"_blank\" rel=\"noopener\">here<\/a>)<\/li>\n<li>the two versions of the Statistical Data Analysis Plan (DAP) setting the frame for Gardasil\u00ae approval (<a href=\"https:\/\/www.zenodo.org\/record\/1434216\" target=\"_blank\" rel=\"noopener\">here<\/a> and <a href=\"https:\/\/www.zenodo.org\/record\/1434220\" target=\"_blank\" rel=\"noopener\">here<\/a>)<\/li>\n<li>the 2006 VRBPAC background document on Gardasil\u00ae Phase III studies\u2019 results (<a href=\"https:\/\/zenodo.org\/record\/1434214\" target=\"_blank\" rel=\"noopener\">here<\/a>)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>The complete email correspondence with Cochrane (2012-2018) is available <a href=\"https:\/\/zenodo.org\/record\/1434757\" target=\"_blank\" rel=\"noopener\">here<\/a>.<br \/>\nAll letters to Cochrane (December 10th, 2012 \u2013 December 8th, 2013 \u2013 December 23rd, 2013 \u2013 August 19th, 2014 \u2013 April 17th, 2017) are available <a href=\"https:\/\/zenodo.org\/record\/1434611\" target=\"_blank\" rel=\"noopener\">here<\/a>.<br \/>\n<small><br \/>\n*co-signed by Abby Lippman, Genevi\u00e8ve Rail, Lyba Spring, Anne Taillefer, Neil Arya, Pierre Biron, Fernand Turcotte.<br \/>\n** these comments are no more available on the dedicated website of the Cochrane HPV vaccines review.<\/small><\/p>\n          <\/div>\n        <\/li>\n        \n          <\/ul>\n  <\/div>\n\n\n\n\n<h2 class=\"wp-block-heading\">Book: La piq\u00fbre de trop? (One Injection Too Many?)<\/h2>\n\n\n\n<div class=\"block-accordeon\">\n      <ul class=\"accordion\" data-accordion data-multi-expand=\"true\" data-allow-all-closed=\"true\">\n              \n        <li class=\"accordion-item\" data-accordion-item>\n          <a href=\"#\" class=\"accordion-title\">more<\/a>\n          <div class=\"accordion-content\" data-tab-content>\n            <p>The HPV vaccine \u2013 also known as \u201cvaccine against cervical cancer\u201c \u2013 was celebrated as a remarkable medical breakthrough. But is cervical cancer a public health threat in industrialized countries? What kind of clinical records do actually exist? And first and foremost: how did this vaccine manage to become accepted so quickly despite its record-breaking price? The <a href=\"https:\/\/editions-xenia.com\/livres\/hpv\/\" target=\"_blank\" rel=\"noopener\">book<\/a> analyses how a stunning success story came to life and features today\u2019s state of knowledge, the published studies and the unanswered questions. It exposes the tremendous extent of the influence maze created by the vaccines&#8217; manufacturers. Xenia publishing, Vevey, March 2010.<\/p>\n          <\/div>\n        <\/li>\n        \n          <\/ul>\n  <\/div>\n\n\n\n\n<p class=\"back\"><a href=\"https:\/\/www.re-check.ch\/en\/projects\/\" data-type=\"page\" data-id=\"15015\"><i class=\"icofont-rounded-left\"><\/i> back<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Since 2008 Catherine Riva and Serena Tinari are investigating the case of HPV vaccination. It\u2019s an issue of public interest, as these vaccines are recommended to millions of healthy individuals. You\u2019ll find below all our publications, open letters, posters, and the regulatory documents we have obtained from the US Food and Drug Administration (FDA) through<a class=\"excerpt-read-more\" href=\"https:\/\/www.re-check.ch\/en\/projects\/hpv-vaccination-2\/\" title=\"ReadHPV Vaccination\">&#8230; Read more &raquo;<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":15015,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-full-width.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-18567","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/pages\/18567"}],"collection":[{"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/comments?post=18567"}],"version-history":[{"count":13,"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/pages\/18567\/revisions"}],"predecessor-version":[{"id":20391,"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/pages\/18567\/revisions\/20391"}],"up":[{"embeddable":true,"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/pages\/15015"}],"wp:attachment":[{"href":"https:\/\/www.re-check.ch\/en\/wp-json\/wp\/v2\/media?parent=18567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}